The group, which currently runs around 50 Patisserie Valerie outlets in England, has acquired a 15-year lease on the four-storey building on Western Road for an undisclosed premium.
Patisserie Valerie will trade from the ground and first floors of the 2,800sqft site near the centre of Brighton.
Rob Meadows of Davis Coffer Lyons who advised the property’s landlord, said: “We are currently receiving enquiries from prospective restaurant occupiers for this area, with its proximity to Brighton, and its wide and affluent catchment.
“Historically, the retail and leisure quantity and range in Hove hasn't always reflected it’s demographic, but it is now attracting many more big names, which may also be linked to some very successful mixed use developments that have completed recently in this region."
The move comes as part of Patisserie Holdings’ plan to rapidly expand the brand, which has grown by 50 per cent in the past 12 months.
The group expects to soon open a further site in Birmingham Pavilions, Henley-on-Thames and Richmond.