The new venue will aim to replicate the offering of Il Calandrino, the casual dining concept attached to Le Calandre in Padua, north-east Italy.
Il Calandrino London will serve breakfast, lunch and dinner, as well as a range of pastries and coffees, and there are plans for a small deli counter selling take-away food.
Owner Raffaele Alajmo is understood to be looking at a site in Sloane Square and hopes to launch before the end of the year, possibly as early as this summer.
A spokesman for the restaurant said that the London outpost would act as an advertisement for the fine dining restaurant in Italy.
If successful, he said the company would look to launch two further restaurants in the next five years, with New York and Hong Kong named as likely locations.
Le Calandre, number 49 in the S.Pellegrino World's 50 Best Restaurants list last year, reopened at the beginning of February after a month-long refurbishment of its dining room.
Its new look aims to better reflect the philosophy of the kitchen, with its emphasis on quality raw materials. The design eschews white linen tablecloths in favour of bespoke wooden tables.