Blanc had to have two operations after he broke his leg and ankle in six places during a fall downstairs at his home on 1 March.
Le Manoir's general manager Philip Newman-Hall, executive chef Gary Jones and chef patissier Benoit Blin, will continue to run the restaurant during that time, but Blanc will be on hand at the restaurant for his team while he recuperates.
"I place my complete trust in their professionalism and I know they will provide guests with the very best experience," he said.
The French chef, who was discharged from the John Radcliffe Hospital in Oxford yesterday, the same day Le Manoir celebrated its 26th anniversary, said he would be using his time constructively.
"I cannot praise the surgeons and staff of the John Radcliffe highly enough. They have looked after me exceptionally well and made sure I did not suffer unnecessary pain.
"I am trying to look at this as an opportunity to write at least one of the books I have been meaning to get around to," he said.