Murphy, who told BigHospitality in March that he wanted to leave the esteemed hotel to get more in touch with produce and the chance to win a Michelin star, joined the five-star Manchester hotel this week.
The American-born chef will be looking to repeat his previous success outside the UK, having previously acquired a rising two-Michelin star status from Ronnums in Austria.
He said: “I am delighted to be joining the team at The Lowry Hotel, with so much great produce on our doorstep. I am looking forward to working with the farmers and suppliers to provide our customers with the best quality products.
“I believe a satisfying dining experience requires more than just successful pairings of flavours, I spend a lot of time thinking about the evolution of a meal and my menus are a culmination of that. In the end it’s all about the guest and what the guest wants, a job well done is the excitement in the face of our guests and the returning customer."
The 165-bedroom Lowry Hotel also features a River Restaurant and River Bar.
A replacement for Murphy has not yet been found for the River Restaurant at The Savoy, although a spokesperson for the hotel told BigHospitality the recruitment process is in the final stages.