The 3,637 sq ft restaurant will be located in the new leisure extension at the Silverburn shopping centre, which is owned and managed by Hammerson.
Richard Collier, property director at Five Guys, said: "Silverburn was identified immediately as we planned the expansion of the Five Guys brand in Scotland. It is a highly successful destination popular with consumers from throughout the region and the leisure extension creates the perfect opportunity for Five Guys."
Other restaurants due to open in the 100,000 sq ft leisure extension at Silverburn include Chimichanga, Carluccio’s, TGI Friday’s, Cosmo, Pizza Express and Zizzi.
Chris Daly, catering leasing executive at Hammerson, said: “Five Guys’ decision to open in Silverburn is confirmation of the centre’s status as a leading retail and leisure destination in the Glasgow region.
"Their arrival completes the leisure extension’s offer, and will significantly add to Silverburn’s already strong retail success."