The 140 cover restaurant will be set across two floors and feature a Northern Italian inspired menu and wine list created by Hartnett and new Head Chef Richard Lloyd, formerly sous chef at Hartnett, Holder and Co.
The restaurant will also feature a food and wine shop adjacent to the restaurant, specialising in freshly prepared pasta, sauces and Italian wines, all to take away.
Hartnett said: “I am thrilled to be opening Café Murano in the heart of Covent Garden’s Opera quarter. This area of London is cultured but laid back and that chimes completely with our approach to dining.
“I am looking forward to working with Richard, whose maturing talent I have witnessed at Hartnett, Holder and Co., and to making Café Murano Tavistock Street a unique and valued addition to the area.”
The original Café Murano opened on St James’s Street in 2013 and has been nominated for the 2015 GQ Awards Restaurant of the Year.