The scheme - which is being jointly delivered by Transport for London and Taylor Wimpey - will straddle both sides of Kingsland High Street and feature 15,000 sq.ft of leisure and retail space.
Shoreditch-based CF Commercial has been appointed to source operators for the project.
The property agency – which specialises in creating unique developments - believes consumers are beginning to reject mainstream brands in favour of independent shops and eateries.
Craig Fisher, founder and director of CF Commercial, said: “Dalston is an iconic location within London, and needs to have a retail and leisure scene that matches its position as a hub of creativity and innovation, which larger brands will not deliver.”
The Western Curve development is one of a growing number of sites to ban high street chains in favour of smaller businesses.
Pop-up mall BOXPARK Croydon has announced that it will consist of uniquely independent food and drink outlets when it opens in 2016.
Dalston Western Curve is one of several regeneration projects taking place in the area, alongside a number of new housing schemes and a refurbishment of the Kingsland Shopping Centre.