The restaurant will replace the Tower Lounge bar which currently operates in the venue, following a multi-million pound investment.
The operator of the restaurant will invest £2m into the development while Blackpool Council will contribute a further £400k towards building works.
Joe Teixeira, chief executive of Harry Ramsden’s, said: “With the town continuing to attract record numbers of visitors, we believe the time is right to further invest in Blackpool. Having served the generations for over 85 years at Harry Ramsden’s, we pride ourselves on being a family brand.
“Within Blackpool Tower, as well as memorable visit to a world class attraction, we aim to create an equally memorable dining experience for local and visiting families, in surroundings which the local community can be extremely proud.”
Councillor Mark Smith, cabinet member for business and economic development, said: “We are delighted to be able to finally announce details of this important development. The private investment being made in Blackpool’s most prominent public asset and the jobs it creates is yet another demonstration of the steps the town has taken in creating a vibrant economy.
“This is a clear message to potential developers – Blackpool is the town to invest in.”
The project will create 100 new jobs in the area and will safeguard a further 30.