The first site opened in the Manchester’s Corn Exchange two months ago.
The 150-cover restaurant includes a cocktail bar, eat-at kitchen bar and a dining area that extends onto the station’s mezzanine terrace overlooking the main concourse.
It has been created in partnership with Individual Restaurants and Piccolino owner Steven Walker and offers 'affordable' Italian food.
D’Acampo said: “After a year of planning, I can’t wait to welcome guests to My Restaurant, Euston Station. I want to give commuters and local residents a proper taste of Italy. I am so excited to be a part of the new food landscape in Euston and every effort has been made to make sure our guests have a truly authentic Italian experience.”
The restaurant opens from 7am until 11pm most evenings and has been designed with the needs of a traveller in mind, equipped with mobile charging points, free wifi and washrooms.
It has been opened under franchise with SSP as part of a £12.5m plan to remodel Euston in to a 'destination station'.
Simon Smith, CEO of SSP UK and Ireland, said: “Gino D’Acampo – My Restaurant at Euston is set to become a must-visit destination for those looking for a bite to eat or a drink on their way home, as well as those who live and work in the area. We’re delighted to be working with Gino and his team to bring authentic Italian cuisine to one of London’s most important stations.”