The Michelin-starred company is tipped to take a prime spot in the city’s No.1 Spinningfields development, according to the Manchester Evening News.
Plans for the 19-storey site include a rooftop bar, restaurant, and terrace as well as space for cafes and restaurants on the ground level.
The £73m project is currently under construction and is due to open in 2017.
A representative for D&D told BigHospitality: “I can confirm that we are looking at a site in Manchester and we will make an announcement when a deal is done.”
The London-based group is also set to open its third restaurant in Leeds later this year.
It is negotiating on several sites in ‘big cities around the UK’ following the success of its regional venues, co-founder Des Gundewardena told BigHospitality’s sister site MCA last year.
D&D owns and operates 35 restaurants in London, Leeds, Paris, Tokyo and New York.
Two of its venues – Launceston Place and Angler in London – currently hold Michelin stars.