The 110-cover site will launch in April, just over 25 years since the brand first opened on Fulham Road.
The new restaurant will be inspired by ‘intricate Thai architecture’ and feature stone carvings, marbled panels and ‘banquette style’ seating.
Andy Holman, Patara managing director, said: “Patara has a strong brand identity symbolising authentic Thai tradition. We are very excited about expanding our restaurant portfolio across London and look forward to welcoming new and existing customers to our Patara restaurant in Hampstead.”
The restaurant will open for lunch, Thai-style afternoon tea and dinner with dishes including Chor Muang - hand-crafted Flower Dumplings with Caramelised Chicken, Sweet Turnip, Peanut, and Crispy Shallot filling, topped with Coconut Cream reduction; and Pan-seared Black cod with Ginger, Shiitake Mushrooms, Pickled Soya and Yellow Bean Sauce.
Patara opened its fifth London site on Berners Street in November, joining its restaurants in Soho, Oxford Circus, Knightsbridge and South Kensington.
Outside the capital the group has venues in Bangkok, Geneva, Vienna, Singapore & Beijing.
Patara will open at 82 Hampstead High Street in April.