The group – which specialises in meat, bread and beer – will open a 220-cover bar and restaurant in a former 1930’s building society.
It will feature an extended beer menu, with 24 varieties on tap, alongside 92 different varieties of gin.
The new 5,600 sq.ft venue will be 60 per cent larger than the current Cambridge site
Richard Holmes, co-owner of Pint Shop, said: “We’re incredibly excited about Oxford and just can’t wait to get in and get it open! The location is perfect and we’re confident we can make it a real success, there’s a massive gap in the Oxford market for us.
"Being in the thick of the action in the cultural hub yet again is really exciting, it means we can pack the place out all day long.
“Whist it will be more evolution than revolution, there will be plenty of surprises and cool new things to get excited about in Oxford.”
Pint Shop will open on George Street, Oxford in late summer 2016.