The group's owner CG Restaurants and Bars is investing £1.5m in converting a 6,700 sq.ft retail and office space in the Deansgate area of the city.
The bar is set to open in summer 2017 and will be the tenth Dirty Martini in the UK.
It marks the first stage of a planned national roll-out of the brand, which opened a site in Cardiff last September.
CG Restaurants and Bars said Dirty Martini was working well outside the capital and had exceeded budgeted sales by 10 per cent.
Scott Matthews, CEO at Dirty Martini, said: “We are excited about opening our first site outside London in the North, in Manchester. Our recent expansion in Cardiff has been a huge success, and as a result we are progressing with our national expansion strategy with confidence.”
Dirty Martini began in a Covent Garden basement and has since grown to a nine-strong group with sites in Bishopsgate, Clapham, Hanover Square, Islington, Monument, St Paul’s and Minories.
It is the latest London-based group to expand to Manchester, following Wahaca, Hawksmoor, Pho and Drake & Morgan.