It is understood that strong interest from investors amid the booming London hotel market has prompted Amaris to seek a possible sale.
CBRE has been appointed to manage the process, with offers being sought for both the lease and the business.
John Brennan, chief executive of Amaris, said: “Amaris Hospitality has commenced a process to potentially sell our DoubleTree by Hilton, Chelsea, property.
“Amaris Hospitality has been making considerable progress in transforming its existing estate and physical product through smart investment and strategic brand management.”
It invested £30m in converting three of its hotels in Edinburgh, Glasgow and Dublin to Hilton brands in in 2015.
Amaris is also planning to expand the Jury's Inn chain in key cities and airport sites around the UK.