The company will open the 100-cover, 2,600 sq ft space at the Frenchgate Shopping Centre on the site of the former Ed's Easy Diner unit, after agreeing a deal with The Frenchgate Partnership.
It will offer "freshly made, traditional American fare including fried chicken, burgers and pulled pork alongside a range of classic side dishes".
"Frenchgate Shopping Centre is an ideal location for our debut site and we are excited to start sharing our fantastic and authentic food in Doncaster," says Lee Edwards, founder of Shake N Burger. "We feel lucky to join the strong dining line-up at a time of great investment and redevelopment within the centre, which we are only set to benefit from."
The brand will join a range of fast-casual and casual dining groups in the centre, including Patisserie Valerie, Cosmo, Costa, KFC, and Chopstix Noodle Bar.