The Marylebone site, dubbed the ‘world’s longest running pop-up’, launched in 2012 on a two-year lease, but has run for five and a half years.
Now the building housing the restaurant is being demolished to make way for a luxury hotel.
MeatLiquor W1 will remain open on a month-by-month basis until its closing date is confirmed.
“We are shutting the doors of W1 as a heart-breaking necessity,” said Scott Collins, co-founder and managing director of MeatLiquor.
“Having originally taken over that site from a failed Italian restaurant in an area with no footfall and very little trade, we are so proud to have grown W1 into a site that has been the bedrock of the MeatLiquor business.”
MeatLiquor began life as the Meatwagon burger van and has since grown to 12 sites across London, Brighton, Bristol and Leeds. The group also teamed up with Deliveroo to open its first delivery-only site in Canary Wharf earlier this year.
The company said in a statement it was looking towards its ‘next chapter’ with plans for further UK expansion.