Macellaio, which means butcher, will open the 60-cover site daily from 12-11.30pm from 21 July.
The group is famous for its use of the almost comically muscly Fassona beef, which is sourced from Piedmont in Italy and has unusually low levels of fat and cholesterol.
The Clapham opening will keep the group’s part restaurant, part butchershop ethos, with beef butchered and dry-aged on-site for five to seven weeks.
It will also feature over 100 Italian wines hand-picked by founder Roberto Costa, who hails from Liguria, with a mix of popular and lesser-known varieties.
Macellaio’s executive chef will oversee the menu, which will range from steaks cooked simply with rock salt and olive oil, to homemade tagliatelle.
Costa launched Macellaio in the UK in South Kensington in 2012, and has since opened sites in Exmouth Market and Union Street.
He told BigHospitality in April that he is also planning to launch a string of more affordable Italian restaurants under the Osteria Number 8 brand, with the first expected to open this year.