The Joe Grossman-led group has taken on the former Piccolo Italian restaurant site, on the corner of Meeting House Lane and Ship Street.
Patty & Bun is the first of the new wave of burger restaurants to secure a prime site in Brighton & Hove. Brands including Byron and Honest Burger have been trying to open in the south coast city for some time but have been hampered by a lack of restaurant property in prime locations.
MEATliquor opened back in 2013 in an off-pitch location near London Road close to Brighton Station.
Patty & Bun currently operates eight sites in London plus a permanent residency at golf venue Swingers LDN. The group is also set to open at the former BBC headquarters in Shepherd’s Bush later this year. Its most recent opening was the ex-Book & Comic Exchange site in Pembridge Road near Notting Hill Gate station.
Patty & Bun is known for its creatively-titled burgers, with a menu that includes the Ari Gold (a cheeseburger) and the Lambshank Redemption (lamb patty with coriander and chilli, pickled aubergine and cumin aioli).
Last summer, it secured £2m in growth funding.