The 39-room property, which has been under construction for six years, occupies the former headquarters of the Baptist Church in Holborn.
It will feature a restaurant and cafe overseen by executive chef Tony Fleming, who won a Michelin star at Angler at D&D London’s South Place Hotel.
The Baptist restaurant, occupying an octagonal former chapel space, is described as bringing a “lightness and creativity” to the traditional grill model, with table-side trolley service.
The ground floor Café L’oscar will offer breakfast, lunch and evening dining, and feature an illuminated onyx bar and mirror-lined walls and ceilings.
Michael Voigt, formerly of The Arch in London, will manage the hotel.
L’oscar hotel has been designed by French architect Jacques Garcia, who created the interiors for the Nomad Hotel in New York, where chef Daniel Humm – of the world’s number one restaurant Eleven Madison Park – oversees the food and beverage offering.
Last year the L'oscar hotel received a £21m loan from OakNorth bank, which backed Leon in a £19m funding package in 2016, with a further £3m from RM Funds.