The company, which runs more than 1,000 aviation-themed restaurants internationally - including 25 owned by US rapper Rick Ross – has taken on the former HSBC Bank site for a two-storey restaurant that will open seven days a week.
Wingstop launched in Texas in 1994 and was named the fastest growing chicken chain in the US in 2016, according to Nation’s Restaurant News.
It offers 11 flavours of wings including spicy Atomic, Hickory Smoked BBQ, Hawaiian and Lemon Pepper, alongside sides and fries.
Last year the company signed a franchise deal with London-based Lemon Pepper Holdings with plans to grow to 100 sites in the UK over the next 12 years
It has also taken a unit at the upcoming Boxpark Wembley, which opens later this year.
Wingstop's central London launch marks another change to the rotating Cambridge Circus line-up. Over the past year Italian restaurant Vico has been replaced by Shake Shack and Polpo’s Ape & Bird pub has become a BrewDog.
Property consultants Lambert Smith Hampton advised on the Wingstop deal.