The launch, first announced in 2016, will see the group bring its mix of Japanese, Brazilian and Peruvian cuisine to the historic Market Building.
A job advertisement for numerous positions posted on Code says the restaurant will open in October.
Sushisamba will take over the entire upper level of the east side of Covent Garden's Opera Terrace – previously home to Brasserie Blanc and Chez Gerard – with a 9,000 sq ft site and balcony.
While the group’s restaurant in London’s Heron Tower houses a huge orange tree sculpture, the new location promises a “living ceiling” with plants and flowers hanging above diners’ heads.
Sushisamba's owner Orange Brands Management says Covent Garden is a "natural fit" for the restaurant.
The new site will feature a 130-cover dining room and private dining area with its own entrance and a hidden speakeasy bar. There’ll also be a 10-cover sushi bar and open kitchen where guests can watch the chefs at work.
It is set to serve Sushisamba's "unique blend" of fusion cuisinse, with new signature dishes.
Cocktails will be created by Rich Woods - who’s also worked on the drinks offer at Adam Handling’s new Hoxton venture.
The global Orange Brands Management group also owns London’s Duck & Waffle and Duck & Waffle Local.
It opened the first UK Sushisamba in Heron Tower in 2012, with Duck & Waffle following soon after.
Sushisamba also operates sites in Miami, Las Vegas and Amsterdam.