He will cook his last service on 5 January before joining Miele GB as development chef.
Scott joined Sudbury House in 2014, overseeing Restaurant 56 - which has since won three AA Rosettes.
He appeared on Great British Menu, representing the Central region, in 2016.
Scott wrote on Twitter: “I wouldn’t change the last five years at Sudbury House and my baby Restaurant 56 for anything, but all good things sometimes come to an end…and it’s a real shame when these decisions aren’t your own.
“I’ve worked at an exceptionally high standard all of my career and I’m not prepared to ‘dumb down’ my work ethic so it’s time to find a new challenge.”
Scott was previously chef de partie at Simon Rogan's L’Enclume and head chef at Mallory Court in Warwickshire, where he retained a Michelin star for three years.