Berkshire Live reports that the group, known for its fried chicken sandwiches and nuggets, launched in Reading’s The Oracle shopping centre this week.
Chick-fil-A, pronounced chik-fil-AY, has been testing the water in the UK for some time with a pop-up in London’s Islington in 2015 and Edinburgh last year.
The company was founded by S. Truett Cathy in Atlanta in 1967 and now trades from over 2,000 locations across the US.
But it has faced controversy over its founders’ religious beliefs and reported donations to groups with a record of anti-LGBTQ discrimination.
Chick-fil-A’s first international restaurant under franchise opened in Toronto in September and was met by protests from LGBTQ activists.
All the brand's US restaurants close on Sundays, Christmas and Thanksgiving, though it is unknown if the Reading site will also do so.
US chains have historically had a mixed reception in the UK. Though Five Guys is on track to break 100 sites this year, brands such as MOD Pizza and Smashburger have struggled to make a similar impact.