Mozzasando will launch in the former Obicà site in South Kensington on 20 January.
It will serve sandos based on breaded chicken and veal Milanese, alongside fries; chilli fries with beef ragu and nduja sauce; and negronis on tap.
The sandos will cost around £7.50 and be available to takeaway or eat in the 32-cover dining room.
Yau says he was inspired by discussions with former Soho sandwich purveyor Frank Salvoni, who believed a Milanese concept could be successful.
“I always wondered in the soul-searching moments for that golden goose whether Frank’s Milanese could become the new champion for an Italian fast food concept," says Yau. "Imagine... if this could merge with the Japanese aesthetics of the katsu sando.”
Yau is also set to open a further three 'Asian gastronomy' restaurants in London next year; two in Canary Wharf and one at the Westfield London shopping centre in Shepherd’s Bush.
His prolific career as a restaurateur includes founding the Hakkasan and Busaba chains, as well as Soho’s The Duck and Rice pub.