The group, which operated four sites across the capital in Soho, Charing Cross, Fitzrovia and White City, said the decision to close is a result of the financial hit taken during the Coronavirus pandemic coupled with the forthcoming end of the Brexit transition period in late December.
In a statement posted to its Instagram page, the group said: "Sadly we have to announce that after more than 10 wonderful years in London, Herman ze German will permanently close all London locations. Covid-19 has hit us really hard, as it probably has most of you too.
"Knowing that Brexit will follow at the end of this year, we had no other choice but to pull the plug.
"There is no way for us to go any further with the restaurants in the UK.
"We are extremely gutted as we put our heart and soul into this project, delivering you our delicious Currywurst and German beers. And we loved it!
"Many thanks for supporting us for so many years."
Serving a menu that majored in the Berlin street food classic currywurst, Herman Ze German was founded in 2008 by Azadeh Falakshahi and Florian Frey.
As well as its four London sites, the group also expanded to Germany during its lifetime, opening both a restaurant and a food truck in the city of Lörrach.
In March last year the group established its first UK location outside of the capital at Birmingham’s Grand Central shopping centre, but subsequently closed the site eight months later in November.