Taking over the former Café Monico site on Shaftesbury Avenue, which is part of the Geilgud Theatre, the 5,000sq ft site will be spread over basement, ground and mezzanine floors, with extensive frontage onto Shaftesbury Avenue.
Dean Gambles & Co acted on behalf of Macellaio RC, with Davis Coffer Lyons representing Delfont Mackintosh Theatres, which owns the Geilgud.
Costa is known for injecting theatre into his restaurants, and Macellaio RC's new West End flagship will be no different, featuring a giant charcoal barbecue grill as its centrepiece.
A wide variety of cocktails will be available to accompany matched cuts of meats, alongside a vast selection of Italian wine.
“It’s fitting that this exciting letting has completed as the West End begins to spring back to life, and it signals the confidence in its recovery," says Sally French, associate director at Davis Coffer Lyons.
"We’ve witnessed first hand this week how keen customers have been to return to their favourite dining destinations, with outdoor trade encouraging pending a full reopening next month. We look forward too, as do so many, to the return of all the fantastic shows that Theatreland has to offer.”
Macellaio (which means butcher) started life in Italy in 2002 when Costa opened a steak-focused restaurant in his native Liguria.
Costa brought the concept to London in 2012 and currently operates sites in South Kensington, Exmouth Market, Fitzrovia, Southwark and Battersea.
In December last year Costa also opened Casacosta in Fulham.