The 90-seat site is significantly bigger than SpiceBox's original 30-cover restaurant in Walthamstow, which was opened by founder Grace Regan in January 2019.
SpiceBox has gained a huge following for its menu of curry house classics reimagined with a plant-based spin.
The Leytonstone menu will feature a host of new dishes, including additions to SpiceBox’s weekend brunch offering.
While details of the new dishes are still being kept under wraps, 'signature' plates set to feature include the jackfruit jalfrezi; shroom keema with a plant-based mince of chopped mushrooms, walnuts, soya and peas; and the red lentil tarka dhal served with kachumber, pickled pink onions, brinjal chutney, turmeric pickle and crispy onions, which was voted Best Dhal in Britain at the British Dhal Festival 2018.
SpiceBox Leytonstone represents the next step for Regan in her vision for the brand, which she initially established as a street food concept.
The restaurant's commitment to sustainability and reducing waste will be as strong as ever, with the popular Tiffin Club that allows guests to get their takeaways in a reusable metal tiffin continuing.
SpiceBox will also be running deliveries in house all via electric bikes.