Opening in September, Santo Remedio Taqueria will take over the site on Great Eastern Street previously occupied by ‘healthy’ grab-and-go brand Pod.
The location is close to the Rivington Street site where Edson and Natalie first launched Santo Remedio back in 2016.
After it opened the restaurant received glowing reviews, but the team were forced to shut up shop after just five months citing problems 'outside their control'.
The pair subsequently went on to secure a new permanent home for the brand near London Bridge in 2017 after successfully raising £40,000 through a crowdfund campaign.
Discussing the new opening on Instagram, Edson and Natalie said: "We're delighted to announce that our second restaurant - Santo Remedio Taqueria - will open in Shoreditch this September.
"An ode to the bustling taquerias of Mexico, we can’t wait to share our corner of Great Eastern Street with you, complete with all your favourites from London Bridge, plus a few new specials, and that unmistakeable Mexican hospitality."
Edson, who recently launched his first cookbook, was previously head of menu innovation at Mexican group Wahaca, working closely with co-founders Thomasina Miers and Mark Selby.